Протективний вплив альфа-ліпоєвої кислоти на серцево-судинні захворювання, зумовлені оксидативним стресом
DOI:
https://doi.org/10.30978/HV201811021Ключові слова:
альфа-ліпоєва кислота, біохімічна дія, серцево-судинні захворювання, цукровий діабет, ендотеліальна дисфункція, оксидативний стресАнотація
Стаття присвячена розгляду протективних властивостей альфа-ліпоєвої кислоти в пацієнтів кардіологічного профілю, зокрема із супутнім цукровим діабетом 2 типу, які становлять групу високого й дуже високого серцево-судинного ризику. Досить докладно розглянуті сучасні патогенетичні механізми ушкодження судинної стінки при дисфункції ендотелію, оксидативному стресі в пацієнтів із серцево-судинною патологією, зокрема із супутнім цукровим діабетом 2 типу. Особливу увагу приділено ролі патогенетично обґрунтованої терапії із застосуванням альфа-ліпоєвої кислоти, що має широкий спектр плейотропних ефектів і впливає на показники оксидативного стресу, атерогенну дисліпідемію та ендотеліальну дисфункцію, запалення, атеросклероз. Систематично, спираючись на дані доказової медицини, викладено особливості впливу альфа-ліпоєвої кислоти на метаболічні процеси в організмі, її роль у системі антиоксидантного захисту, а також її цитопротективні властивості, що обґрунтовують раціональність застосування альфа-ліпоєвої кислоти в пацієнтів кардіологічного профілю.
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